Melgares. MA
Institute of Oncology and Radiobiology
Cuba
Title: Localized chemotherapy as treatment of advanced and recurrent epithelial conjunctival tumors
Biography
Biography: Melgares. MA
Abstract
Introduction and objective: Conjunctival epidermoid carcinoma has not a standardized procedure of treatment. There are preclinical evidences in rabbits and horses and in vitro studies with melanoma cell lines that demonstrate the efficiency of localized cisplatin therapies. The Ophthalmology Service of the Institute of Oncology and Radiobiology of Cuba has developed a scheme of treatment for this pathology consisting in neo and adjuvant chemotherapy combined with conservative surgery for patient who presents recurrences of this kind of tumors. The results are described in the present work. Materials and Methods: A sample of 26 patients (90 % of them with histo-pathologic diagnose of moderate differentiated conjuntival epidermoid carcinoma). Patient were treated with a patented formula that contains cisplatin (1 -3 mg). Such formula was administered subconjuntivally and topically, six doses in 45 days. Results: The simple was composed by 14 men (4 of them HIV carriers) and 12 women. The 81 % of patients was controlled by 40 months alter finishing the treatment. A patient passed away due to another primary tumor in stomach, a year after finishing the treatment. Four patients showed recurrences (3 between 8 and 16 months, one at 60 months after finishing treatment). An orbitary removal was performed in theses cases. All patients are in surveillance and reported as stable. Most frequent adverse effect associated to the procedure were: chemical conjunctivitis, tearing (grade 1, mild) and subconjunctival bleeding (grade 2, moderate) CTC (Common Terminology Criteria, version 4.0, 2009). Conclusion: The procedure is effective and harmless.