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Galina Chernakova

Federal State Institution; ”Herpes clinic” Russia

Title: Mixt-infections and inflammatory ophthalmological diseases: clinical and laboratory observations

Biography

Biography: Galina Chernakova

Abstract

Statement of the Problem: In recent years, doctors of all specialties, including ophthalmologists faces the problem of mixed infections. Recurrent inflammation of eye tissues is often the result of infection by several types of pathogens.  

Methodology & Theoretical Orientation:  34 patients (14 men and 20 women) with various forms of inflammatory ophthalmological diseases and a positive result of the determination of the genetic material (DNA) of mycoplasmas (Mycoplasma hominis, Ureaplasma urealyticum) and/or Chlamydia (Chlamydia trachomatis) in tear fluid and/or urine by polymerase chain reaction (PCR) were followed-up for the period from 2013 to 2016. All patients were examined for the presence of DNA of the herpes viruses, adenoviruses and enteroviruses in biological fluids. After consultations of related professionals all patients received local and systemic (antibacterial and antiviral) therapy, after which monitoring laboratory tests were performed.

Findings: among the clinical forms dominated inflammation of anterior segment (conjunctiva, cornea, anterior vascular tract) - 76%. In most patients, mycoplasmas and/or chlamydias formed associations with the herpes viruses (n=19; 56%); only bacterial DNA (Mycoplasma and/or Chlamydia) was detected in 12 cases (35%) – Table 1. In 4 cases Mycoplasma and/or Chlamydia DNA was detected in tear fluid; in urine - in 19 patients; in 10 cases –in both secrets. The appointment of local and systemic causal treatment resulted in relief of the complaints and symptoms, and was also accompanied by negative results of the control laboratory tests.

Conclusion & Significance: More than a half of the patients revealed concomitant viral-bacterial infection (22 cases). The production of bacterial/viral DNA in different biological secrets by PCR method reflects the systemic nature of the infection process, which requires obligate involvement of related specialists (dermatologists, urologists, gynecologists).