Young Cheol Yoo has run a busy cataract and glaucoma surgical practice with special expertise in complex cataract removal using the latest technologies including toric lenses as well as multifocals. He is an expert on optical coherence tomography and standard automated perimetry. Current research interests includes: structure-function relationship in glaucoma, glaucoma in myopia, minimally invasive glaucoma surgery, and validating and commercializing new medical devices
Purpose: To assess the relationship between daily alcohol consumption and intraocular pressure (IOP) in Korean men and women Methods: We explored the effect of daily alcohol intake on high IOP in 7,532 adults who participated in the 2010-2012 Korean National Health and Nutritional Examination Survey (KNHANES). Multiple logistic regression analysis was used to assess the relationship between average daily alcohol consumption and an IOP of ≥ 18mmHg after adjusting for age, body mass index, hypertension, diabetes mellitus, and smoking in each sex group. Results: When adjusted for related factors, the odds of high IOP was 2.57 times (95% confidence interval, 1.239 to 5.314) higher in men with a daily heavy alcohol intake than men with a heavy alcohol intake < 1 per month. However, increased odds of high IOP with daily alcohol consumption were not found among women. Conclusions: After adjusting for age and other confounders, there was a significant relationship between daily alcohol consumption and high IOP in men, whereas the relationship was not significant in women.
Prof.Choun-Ki Joo has his expertise in cataract, cornea, and other basic studies. He is a dean of the college of Medicine, The Catholic University of Korea, and also president of the Catholic Institute for Visual Science
Trehalos has been known to stabilize bilipid membranes and proteins against desiccation, and to have a protective effect against desiccation and oxidative insult in the mammalian eye, which has been made into some tear preparations. In this trial, the efficacy and safety of a novel mixture of 0.01% or 0.02% cyclosporine A(CsA) with 3% trehalose in dry eye were analyzed. Dry eye patients with corneal staining score more than 2 were randomly assigned to receive mixture of 3% trehalose and topical 0.01%(low dose treatment) or 0.02%(high dose treatment) CsA, or placebo to be administered twice daily for 12 weeks. The primary efficacy outcome was a change from baseline in corneal fluorescein staining scores at week 12, and changes at week 4 and 8 were reported as secondary endpoints. Additional endpoints included score changes from baseline in conjunctival staining, strip meniscometry, tear breakup time(TBUT), Standard patient evaluation of eye dryness questionnaire(SPEED) at week 4, 8 and 12 and ratio of 100% clearance in corneal staining. At week 12 of treatment, corneal staining scores were improved in patients treated with high-dose treatment, with significant difference compared to the placebo treatment (p=0.0361). There were no significant difference between low-dose treatment and placebo in corneal and conjunctival staining, strip meniscometry, TBUT, SPEED at week 4, 8 and 12. There were no significant difference between high-dose treatment and placebo in corneal staining at week 4, 8, conjunctival staining, strip meniscometry, TBUT, SPEED at week 4, 8 and 12. Ratio of 100% clearance in corneal staining were 53.13% in placebo, 55.17% in low-dose treatment, 78.57% in high-dose treatment. High-dose treatment is shown to alleviated corneal staining signs of dry eye patients comparably to placebo. Further evaluations would be needed for this mixture to demonstrate being a novel therapeutic agent for dry eye syndrome